Denali Therapeutics

San Francisco, United States Founded: 2015 • Age: 11 yrs
Neurodegenerative disease therapies are developed for Alzheimers, ALS, and Parkinsons.
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About Denali Therapeutics

Denali Therapeutics is a company based in San Francisco (United States) founded in 2015 by Marc Tessier Lavigne and Alexander Schuth.. Denali Therapeutics has raised $347 million across 3 funding rounds from investors including Flagship Pioneering, Baillie Gifford and Arch Venture Partners. The company has 422 employees as of December 31, 2024. Denali Therapeutics has completed 1 acquisition, including Triller. Denali Therapeutics offers products and services including Transport Vehicle Technology. Denali Therapeutics operates in a competitive market with competitors including Biogen, Intra-Cellular Therapies, Amylyx Pharmaceuticals, Poseida Therapeutics and Annexon, among others.

  • Headquarter San Francisco, United States
  • Employees 422 as on 31 Dec, 2024
  • Founders Marc Tessier Lavigne, Alexander Schuth
  • Stage Public
  • Sectors
    Healthcare
  • Phone
    *********
  • Website
    *********
  • Social
    *********
  • Legal Name Denali Therapeutics Inc.
Operational Areas
Healthcare → Biotechnology, Genomics & Life Sciences Research
Healthcare → Biotechnology, Genomics & Life Sciences Research
Healthcare → Healthcare Products & Supplies
Key Metrics
  • Annual Revenue
    $0
    -100
    as on Dec 31, 2024
  • Net Profit
    $-422.77 M
    -191.12
    as on Dec 31, 2024
  • EBITDA
    $-494.08 M
    -174.53
    as on Dec 31, 2024
  • Total Equity Funding
    $347 M (USD)

    in 3 rounds

  • Latest Funding Round
    $499.73 M (USD), Post-IPO

    Feb 27, 2024

  • Investors
  • Employee Count
    422

    as on Dec 31, 2024

  • Investments & Acquisitions
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IPO & Listings of Denali Therapeutics

Denali Therapeutics is a publicly listed company on the NASDAQ with ticker symbol DNLI in USA, operating in the Health technology sector. As a publicly traded entity, the company provides investors with opportunities to participate in its growth story through equity ownership. The listing enables access to capital markets, enhances corporate visibility, and provides liquidity for shareholders while maintaining transparency through regulatory compliance and regular financial disclosures.

Exchange: NASDAQ · Ticker: DNLI . Sector: Health technology · USA

Products & Services of Denali Therapeutics

Denali Therapeutics offers a comprehensive portfolio of products and services, including Transport Vehicle Technology. The company's diverse product and service offerings are designed to meet the evolving needs of its customers, address market demands, and provide comprehensive solutions that drive value creation and customer satisfaction across various segments and use cases.

Primary

Enables brain delivery for neurodegenerative disease treatments.

People of Denali Therapeutics
Headcount 200-500
Employee Profiles 221
Board Members and Advisors 9
Employee Profiles
People
Jason Dugas
Senior Director / Staff Scientist - Head Of Discovery Pharmacology + Automated Lab Facility
People
Leah Frautschy
Vice President, Clinical Manufacturing
People
Tyler Nielsen
Senior Vice President Corporate Finance
People
Laura Hansen
Vice President Of Investor Relations

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Board Members and Advisors
people
Steve Krognes
Board Member
people
Jay Flatley
Board Member
people
Peter Klein
Board Member
people
David Schenkein
Board Member

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Funding Insights of Denali Therapeutics

Denali Therapeutics has successfully raised a total of $347M across 3 strategic funding rounds. The most recent funding activity was a Post-IPO round of $499.73 million completed in February 2024. This substantial capital infusion reflects strong investor confidence in the company's business model, growth potential, and market opportunities. The funding enables strategic expansion, product development, market penetration, and operational scaling to drive long-term value creation and competitive advantage.

  • Total Funding
  • Total Rounds 3
  • Last Round Post-IPO — $499.7M
  • First Round

    (14 May 2015)

  • Investors Count 5
Date Amount Transaction Name Valuation Lead Investors Investors
Feb, 2024 Amount Post-IPO - Denali Therapeutics Valuation

investors

Aug, 2016 Amount Series B - Denali Therapeutics Valuation

investors

May, 2015 Amount Series A - Denali Therapeutics Valuation

investors

Date Amount Transaction Name Valuation Lead Investors Investors
Jul, 2021 Amount Post-IPO - Grab Valuation

investors

Feb, 2021 Amount Post-IPO - Grab Valuation

investors

Jan, 2021 Amount Post-IPO - Grab Valuation

investors

Feb, 2021 Amount Post-IPO - Grab Valuation

investors

Investors in Denali Therapeutics

Denali Therapeutics has secured backing from 5 investors, including institutional and venture fund investors. Prominent investors backing the company include Flagship Pioneering, Baillie Gifford and Arch Venture Partners. This diverse investor base provides strategic capital, industry expertise, and valuable network connections that support the company's growth initiatives, market expansion, and long-term value creation.

All
Venture Fund
Institutional
Investor Description Founded Year Domain Location
Venture capital firm focused on life science companies
Founded Year Domain Location
Investments in life sciences, technology, healthtech, and crypto sectors from global locations.
Founded Year Domain Location
Life sciences-focused venture capital firm
Founded Year Domain Location
Investor Description Founded Year Domain Location
Single family office of Amitabh Bachchan, founder of Amitabh Bachchan Corporation or AB CORP
Founded Year Domain Location
Startup ecosystems are ignited through strategic investments by Signite Partners.
Founded Year Domain Location
Venture capital is directed toward companies in multiple sectors.
Founded Year Domain Location
Venture capital is invested in cybersecurity, fintech, and AI startups.
Founded Year Domain Location

Investments & Acquisitions by Denali Therapeutics

Denali Therapeutics has strategically engaged in corporate development activities, having acquired 1 company. Notable acquisitions include Triller. These strategic investments and acquisitions demonstrate the company's commitment to growth through portfolio expansion, market consolidation, technology integration, and strategic partnerships that enhance competitive positioning and drive long-term value creation.

Investments
Company Name Description Domain Location Founded Year Amount
Bionic investment advisor platform
2016
Fine Asian gourmet food is offered by an internet-first restaurant.
2016
Physical e-commerce kiosks are deployed for rural purchases in Indonesia.
2014
Fine Asian gourmet food is offered by an internet-first restaurant.
2016
Acquisitions
Company Name Description Domain Location Founded Year Amount
Music videos are created and shared through a mobile platform.
2015
Company Name Description Domain Location Founded Year Amount
OVO is recognized as a smart digital payment application.
2017
Bionic investment advisor platform
2016
Physical e-commerce kiosks are deployed for rural purchases in Indonesia.
2014
Physical e-commerce kiosks are deployed for rural purchases in Indonesia.
2014

Financial Statements - Denali Therapeutics

Tata Steel revenue growth over time
Tata Steel profit and loss trends over time
Date Amount Transaction Name Valuation Lead Investors Investors
Jul, 2021 Amount Post-IPO - Grab Valuation

investors

Feb, 2021 Amount Post-IPO - Grab Valuation

investors

Jan, 2021 Amount Post-IPO - Grab Valuation

investors

Feb, 2021 Amount Post-IPO - Grab Valuation

investors

Denali Therapeutics Comparisons

Employees
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Competitors of Denali Therapeutics

Denali Therapeutics operates in a dynamic and competitive business environment, facing competition from various established players and emerging companies in the market. The competitive landscape includes prominent companies such as Biogen, Intra-Cellular Therapies, Amylyx Pharmaceuticals, Poseida Therapeutics and Annexon, among others. This competitive environment drives innovation, market differentiation, and strategic positioning as companies strive to capture market share and deliver value to their customers. Understanding the competitive dynamics is crucial for assessing market positioning, identifying growth opportunities, and navigating the challenges inherent in a competitive marketplace.

Company Name Domain Founded year HQ Location Description
domain founded_year HQ Location
Therapies for neurodegenerative and immunology disorders are developed.
domain founded_year HQ Location
Developer of therapeutics for psychiatric and neurologic diseases
domain founded_year HQ Location
Small-molecule therapeutics for neurodegenerative diseases are developed.
domain founded_year HQ Location
Developer of gene therapies for treating cancer and liver orphan disease by using gene editing technologies
domain founded_year HQ Location
Developer of antibodies to treat complement-mediated neurodegenerative diseases
Company Name Domain Founded year HQ Location Description
domain founded_year HQ Location
Multiple services are booked via an app-based platform.
domain founded_year HQ Location
On-demand services are booked through an app-based platform.
domain founded_year HQ Location
App based platform offering on demand delivery and ride-hailing services
domain founded_year HQ Location
Operates an on-demand hyperlocal delivery app for food and groceries.

Latest news on Denali Therapeutics

Frequently Asked Questions about Denali Therapeutics

When was Denali Therapeutics founded?

Denali Therapeutics was founded in 2015.

Where is Denali Therapeutics located?

Denali Therapeutics is headquartered in San Francisco, United States. It is registered at San Francisco, California, United States.

Is Denali Therapeutics a funded company?

Denali Therapeutics is a funded company, having raised a total of $347M across 3 funding rounds to date. The company's 1st funding round was a Series A of $217M, raised on May 14, 2015.

How many employees does Denali Therapeutics have?

As of Dec 31, 2024, the latest employee count at Denali Therapeutics is 422.

What does Denali Therapeutics do?

Denali Therapeutics was founded in 2015 and is headquartered in San Francisco, United States. Operations focus on the biotechnology sector, where therapies for neurodegenerative diseases are developed. The pipeline includes a small molecule RIP1 kinase inhibitor designed to address Alzheimers disease and ALS by modulating inflammatory signaling and glial dysfunction in the brain. An LRRK2 inhibitor is also advanced for Parkinsons disease treatment.

Who are the top competitors of Denali Therapeutics?

Denali Therapeutics's top competitors include Intra-Cellular Therapies, Juno Therapeutics and Entrada Therapeutics.

What products or services does Denali Therapeutics offer?

Denali Therapeutics offers Transport Vehicle Technology.

Is Denali Therapeutics publicly traded?

Yes, Denali Therapeutics is publicly traded on NASDAQ under the ticker symbol DNLI.

How many acquisitions has Denali Therapeutics made?

Denali Therapeutics has made 1 acquisition, including Triller.

Who are Denali Therapeutics's investors?

Denali Therapeutics has 5 investors. Key investors include Flagship Pioneering, Baillie Gifford, Arch Venture Partners, F-Prime Capital, and Alaska Permanent Fund.

What is Denali Therapeutics's ticker symbol?

The ticker symbol of Denali Therapeutics is DNLI on NASDAQ.

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