Rare Diseases

Companies: 949
Sector: Healthcare
Overview

Rare Diseases is a key segment within the Healthcare sector, comprising 949+ companies actively operating in this space.

This segment represents businesses focused on specific activities and services within Healthcare. Companies in this segment share common characteristics, market positioning, and often face similar challenges and opportunities.

Browse the comprehensive directory of Rare Diseases companies to access detailed profiles, financial information, funding rounds, investor details, and other critical business intelligence for research, due diligence, and market analysis.

Top Companies in Rare Diseases

Discover leading companies in this segment, ranked by company performance and market presence.

Moderna
modernatx.com

mRNA-based therapeutics for diseases including cancer and infections are developed.

Founded 2010
Location Cambridge, Massachusetts, United States
Revenue USD 3.24 B As on 31 Dec 2024
Employees 5,800 As on 31 Dec 2024
Total Funding USD 2.78 B As on 17 Jan 2025

Gene therapies for rare diseases including retinal dystrophies are developed.

Founded 2013
Location Philadelphia, Pennsylvania, United States
Revenue USD 64.73 M As on 31 Dec 2018
Employees 822 As on 31 Dec 2021
Total Funding USD 82.8 M As on 23 May 2014
BridgeBio
bridgebio.com

Therapeutics for genetic diseases are developed through targeted interventions.

Founded 2015
Location Palo Alto, California, United States
Revenue USD 221.9 M As on 31 Dec 2024
Employees 730 As on 31 Dec 2024
Total Funding USD 434.2 M As on 30 Apr 2024

Solutions for genetic diseases are developed using CRISPR-Cas9 genome editing.

Founded 2013
Location Basel, Basel-stadt, Switzerland
Revenue USD 37.31 M As on 31 Dec 2024
Employees 393 As on 31 Dec 2024
Total Funding USD 127 M As on 12 Dec 2023
Forge Biologics
forgebiologics.com

Gene therapies for rare diseases are developed to treat patients.

Founded 2020
Location Columbus, Ohio, United States
Total Funding USD 250 M As on 12 Sep 2022

Developing small molecules for control mechanisms and genes regulation for the treatment of rare diseases

Founded 2015
Location Cambridge, Massachusetts, United States
Revenue USD 80 M As on 31 Dec 2024
Employees 45 As on 31 Dec 2024
Total Funding USD 114.67 M As on 10 Jun 2020

Developer of peptide therapeutics for the treatment of rare genetic deficiencies

Founded 2010
Location Boston, Massachusetts, United States
Revenue USD 130.13 M As on 31 Dec 2024
Employees 283 As on 31 Dec 2024
Total Funding USD 84 M As on 01 Apr 2024
Alnylam
alnylam.com

RNA interference-based therapeutics are developed for multiple disorders.

Founded 2002
Location Cambridge, Massachusetts, United States
Revenue USD 2.25 B As on 31 Dec 2024
Employees 2,230 As on 31 Dec 2024
Total Funding USD 17 M As on 17 Aug 2020

Biologics platform developed for intracellular delivery in rare diseases.

Founded 2016
Location Boston, Massachusetts, United States
Revenue USD 210.78 M As on 31 Dec 2024
EBITDA USD 50.78 M As on 31 Dec 2024
Net Profit USD 65.63 M As on 31 Dec 2024
Employees 183 As on 31 Dec 2024
Total Funding USD 175.25 M As on 31 Mar 2021
Phathom Pharmaceuticals
phathompharma.com

Therapies for gastrointestinal diseases are developed by Phathom Pharmaceuticals.

Founded 2019
Location Menlo Park, California, United States
Revenue USD 55.25 M As on 31 Dec 2024
Employees 427 As on 31 Dec 2024
Total Funding USD 90 M As on 15 May 2019
Generation Bio
generationbio.com

Gene therapies for rare liver and eye diseases are developed.

Founded 2016
Location Cambridge, Massachusetts, United States
Revenue USD 19.89 M As on 31 Dec 2024
Employees 115 As on 31 Dec 2024
Total Funding USD 236.47 M As on 10 Jan 2020

Small molecule drugs for rare diseases are developed.

Founded 1998
Location South Plainfield, New Jersey, United States
Revenue USD 806.78 M As on 31 Dec 2024
Employees 939 As on 31 Dec 2024
Total Funding USD 248.1 M As on 16 May 2023
Krystal Biotech
krystalbio.com

Genetic medicines are developed to address rare diseases.

Founded 2015
Location Pittsburgh, Pennsylvania, United States
Revenue USD 290.51 M As on 31 Dec 2024
EBITDA USD 109.94 M As on 31 Dec 2024
Net Profit USD 89.16 M As on 31 Dec 2024
Employees 275 As on 31 Dec 2024
Total Funding USD 11.25 M As on 22 May 2023
Annexon
annexonbio.com

Developer of antibodies to treat complement-mediated neurodegenerative diseases

Founded 2011
Location San Francisco, California, United States
Employees 100 As on 31 Dec 2024
Total Funding USD 256 M As on 08 Jul 2022
UniQure
uniqure.com

Gene-based therapies are developed for genetic and acquired diseases.

Founded 1998
Location Amsterdam, Netherlands
Revenue USD 27.12 M As on 31 Dec 2024
Employees 209 As on 31 Dec 2024
Total Funding USD 111 M As on 01 Apr 2021
Horizon Therapeutics
horizontherapeutics.com

Developer of drugs for treating rare and autoimmune diseases

Founded 2008
Location Dublin, Ireland
Revenue USD 617.41 M As on 31 Dec 2022
Total Funding USD 61.78 M As on 01 Oct 2014
Mereo BioPharma
mereobiopharma.com

Therapeutics for cancer and rare diseases are developed.

Founded 2015
Location London, England, United Kingdom
Employees 56 As on 31 Dec 2021
Total Funding USD 119 M As on 04 Jun 2020
Harmony Biosciences
harmonybiosciences.com

Developer of therapeutics for rare neurological diseases

Founded 2017
Location Plymouth Meeting, Pennsylvania, United States
Revenue USD 714.73 M As on 31 Dec 2024
EBITDA USD 214.94 M As on 31 Dec 2024
Net Profit USD 145.49 M As on 31 Dec 2024
Employees 268 As on 31 Dec 2024
Total Funding USD 345 M As on 27 Jan 2020

Disease-modifying therapies for degenerative disorders are developed.

Founded 2006
Location Carlsbad, California, United States
Employees 54 As on 31 Dec 2024
Total Funding USD 170.5 M As on 27 Jan 2021
BioCryst
biocryst.com

Developer of small molecule drugs for orphan & autoimmune diseases and antivirals

Founded 1986
Location Durham, North Carolina, United States
Revenue USD 450.71 M As on 31 Dec 2024
Employees 580 As on 31 Dec 2024

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